Ultrasound-Enhanced rt-PA Thrombolysis in an ex vivo Porcine Carotid Artery Model
نویسندگان
چکیده
منابع مشابه
Dual frequency ultrasound-enhanced tissue plasminogen activator thrombolysis in an in vitro human clot model
Introduction: Stroke causes death and disability in patients throughout the world. At present, the only FDA- approved drug for ischemic stroke is recombinant tissue plasminogen activator (rt- PA). Unfortunately, rtPA can cause intracerebral hemorrhage and must use within limited time window (within 3-4.5 hour after onset of stroke). Ultrasound with rtPA loaded liposomes (rtPA_L...
متن کاملFactors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration
Background: To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results. Methods: We enrolled 118 ischemic stroke patients who were treated ...
متن کاملCoronary Arterial Thrombolysis With rt-PA in a Canine Preparation
G4120, L-cysteine, A^mercaptoacetyl)-D-tyrosyl-L-arginylglycyl-L-tt-aspartyl-cyclic(l-»5)-sulfide, 5-oxide, a synthetic cyclic Arg-Gly-Asp-containing pentapeptide, has a high affinity (dissociation constant of 4 nM) for the platelet glycoprotein (GP) Ilb/IIIa receptor. The effects of its intravenous or endobronchial administration on thrombolysis, reocclusion, and bleeding time prolongation ind...
متن کاملAn Inexpensive Ex-Vivo Porcine Laparoscopic Nissen Fundoplication Training Model
BACKGROUND We recently implemented the use of an ex-vivo porcine model to teach residents the fundamentals of performing a laparoscopic Nissen fundoplication. METHODS Residents were trained using intact porcine esophagus, stomach, and spleen placed in a standard video-trainer. They were later asked to complete a survey containing a course evaluation. RESULTS Sixteen residents (R1-R4) comple...
متن کاملComparative lytic efficacy of rt-PA and ultrasound in porcine versus human clots
INTRODUCTION Porcine thrombi are employed routinely in preclinical models of ischemic stroke. In this study, we examined the differential lytic susceptibility of porcine and human whole blood clots with and without the use of microbubbles and ultrasound (US) as an adjuvant. MATERIALS AND METHODS An in vitro system equipped with time-lapse microscopy was used to evaluate recombinant tissue-pla...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ultrasound in Medicine & Biology
سال: 2011
ISSN: 0301-5629
DOI: 10.1016/j.ultrasmedbio.2011.05.011